Anales del Jardín Botánico de Madrid, Vol 76, No 2 (2019)

Chemical and morphological characterization of Allium tuncelianum (Amaryllidaceae) and its antioxidant and anticholinesterase potentials


https://doi.org/10.3989/ajbm.2523

Songul Karakaya
Department of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Turkey
orcid http://orcid.org/0000-0002-3268-721X

Gulnur Eksi
Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Turkey
orcid http://orcid.org/0000-0002-6869-8703

Mehmet Koca
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Turkey
orcid http://orcid.org/0000-0002-1517-5925

Betul Demirci
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Turkey
orcid http://orcid.org/0000-0003-2343-746X

Haluk Caglar Kaymak
Department of Horticulture, Faculty of Agriculture Ataturk University, Turkey
orcid http://orcid.org/0000-0002-0836-7654

Mehmet Emin Kaplan
Department of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Turkey
orcid http://orcid.org/0000-0001-6833-4451

Ozkan Aksakal
Department of Biology, Faculty of Science, Ataturk University, Turkey
orcid http://orcid.org/0000-0003-0760-7502

Abstract


Alzheimer’s disease is the main reason for dementia, which increases with age. Cholinesterase inhibition and antioxidant potentials of extracts and essential oils from bulbs of A. tuncelianum (Kollmann) Özhatay & al., an endemic species to Tunceli (easthern Turkey), were evaluated. The fraction extracted of ethyl acetate had the highest phenolics level, 1,1-diphenyl-2-picrylhydrazyl, and thiobarbituric acid antioxidant capacity. Also, the ethyl acetate fraction presented the highest acetylcholinesterase (15.98 ± 2.76%), and butyrylcholinesterase inhibition (47.33 ± 3.27%). Diallyl disulfide (49.8%), diallyl trisulfide (27.9%) and allyl methyl trisulfide (6.9%) were found to be the major components of essential oil. This paper shows that the ethyl acetate fraction of A. tuncelianum could be a potent source of antioxidant and anticholinesterase components.

Keywords


Allium tuncelianum; anticholinesterase; endemic; essential oil; morphology

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